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In Hampden–Sydney College, there are over 40 clubs on campus. Each club is run by the students. There are political clubs, sports clubs, religious clubs, a student-run radio station, a pep band, and multiple social fraternities. There are also volunteer groups such as Habitat for Humanity and Rotaract.
The college campus is home to a unique volunteer fire department, The Hampden–Sydney Volunteer Fire Department, which provides fire suppression service and non-transport basic life support EMS to Prince Edward County and the college, as well as assisting the town of Farmville Fire Department with fire suppression at nearly all working fires within the town limits on a regular basis. HSVFD, Company 2, is located on the south end of campus near the water tower and the physical plant. Contrary to popular belief, and despite its location and the fact that 90% of the membership comes from college faculty, staff, and students, the fire department is, in fact, not affiliated with the college.
The College has expanded from its original small cluster of buildings on 100 acres (0.4 km²) to a campus of over 1300 acres (5.25 km²). Before 2006, the college owned 660 acres (2.7 km²). In February 2006, the college purchased 400 acres (1.6 km²) which include a lake and Slate Hill Plantation, the historic location of the college’s founding. The campus is host to numerous federal style buildings. Part of the campus has been listed on the National Register of Historic Places as a historic district.